One of the greatest characters in fictional history has had his reincarnation in the form of Dr. House, the main protagonist on a popular TV show. The Doctor has a serious physical ailment and takes massive amounts of a pain killer to cope with the pain. His pain diminished, he then diagnoses diseases and medical problems that no one else can.
Sherlock Holmes was a fictional detective that solved the great mysteries of the late 1880s. Holmes and House are both single with a notable lack of romantic tendency.
House has a friend named Dr.Wilson who he gets vicodin from. Holmes had a friend named Dr.Watson who he got cocaine from. Holmes' street address was 221B; House's is 221B. The one major difference is that House solves medical mysteries while under the influence. Holmes took his drugs to escape and relax. Both are compelling dramas.